The role of interleukin-23 receptor gene polymorphisms rs7517847 and rs10889677 in ovarian cancer pathogenesis in women from Bashkortostan

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Doklady Bashkirskogo Universiteta. 2016. Volume 1. No. 1. pp. 68-73.

Authors

Prokofyeva D. S.*
Bashkir State University
32 Zaki Validi st., 450074 Ufa, Republic of Bashkortostan, Russia
Mingajeva E. T.
Bashkir State University
32 Zaki Validi st., 450074 Ufa, Republic of Bashkortostan, Russia
Faiskhanova R. R.
State Institution of Health Republican Clinical Oncology Center of the Ministry of Health of the Republic of Bashkortostan, Russia
Sakaeva D. D.
State Institution of Health Republican Clinical Oncology Center of the Ministry of Health of the Republic of Bashkortostan, Russia
Khusnutdinova E. K.
Bashkir State University; Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences, Russia
32 Zaki Validi st., 450074 Ufa, Republic of Bashkortostan, Russia

Abstract

In recent years the emphasis is on the role of the immune system in ovarian cancer pathogenesis. An important candidate gene of ovarian cancer association is IL23R which plays a key role in the inflammatory process. We analyzed the frequency distribution of alleles and genotypes of polymorphic loci rs7517847 and rs10889677 IL23R gene between patients with ovarian cancer and healthy women from the Republic of Bashkortostan. The research was established association of polymorphic variant rs10889677 with an increased risk of ovarian cancer (OR: 1.51; 95%, CI (1.17-1.97), p = 0.002).

Keywords

  • ovarian cancer
  • the immune system
  • interleukin-23 receptor
  • the risk of disease
  • the association
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