Synthesis new hydrazides of n-substituted derivatives of methyl 4h-thieno[3.2-b]pyrrole-5-carboxylate

Doklady Bashkirskogo Universiteta. 2019. Volume 4. No. 6. pp. 587-591.

DOI: https://doi.org/10.33184/dokbsu-2019.6.3

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The 4H-thieno [3.2-b] pyrrole-5-carboxylate system is an actively used platform in the design of bioactive compounds. This work to the synthesis of hydrazides of N-substituted derivatives of 4H-thieno [3.2-b] pyrrole-5-carboxylic acidis devoted. With this goal by alkaline hydrolysis of the N-allyl- and N-benzyl derivatives of 4H-thieno[3.2-b]pyrrole-5-carboxylic acid methyl ester were yielded the corresponding acids, which by the action of carbonyldiimidazole to more active acyl imidazolides were converted. The latter were introduced in the reaction condensation with a 65% aqueous solution of hydrazine , which after treatment led to the target pharmacological perspective compounds - 4-benzyl- and 4-allyl-4H-thieno[3,2-b]pyrrole-5-carbohydrazides.