Determination of the 5-methyl-4-[(propylthio)methyl]-2,4-dihydro-3h-pyrazol-3-onantioxidant activity
Doklady Bashkirskogo Universiteta. 2019. Volume 4. No. 6. pp. 597-601.
Authors
Akhmetgalina Yu. E.
Bashkir State Pedagogical University n. a. M. Akmulla
3 Oktyabrskoj revoljucii Street, 450008 Ufa, Republic of Bashkortostan, Russia
Shamukaev V. A.
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences
71 Oktyabrya Avenue, 450054 Ufa, Republic of Bashkortostan, Russia
Baeva L. A.
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences
71 Oktyabrya Avenue, 450054 Ufa, Republic of Bashkortostan, Russia
Yakupova L. R.*
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences
71 Oktyabrya Avenue, 450054 Ufa, Republic of Bashkortostan, Russia
*E-mail: jkupova@anrb.ru
Murzagulova E. I.
Bashkir State University
32 Zaki Validi Street, 450076 Ufa, Republic of Bashkortostan, Russia
Safiullin R. L.
Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences
71 Oktyabrya Avenue, 450054 Ufa, Republic of Bashkortostan, Russia
Abstract
The antioxidant effect of the 4-[(propylthio)methyl]-2,4-dihydro-5-methyl-3H-pyrazol-3-one(I)was measured in a model system of radical chain 1,4-dioxaneoxidation.2,2'-Azo-bisisobutyronitrile was used as an initiator, oxygen from the airwas oxidizer. The reaction was carried at a temperature of 333 Kout. The oxidation 1,4-dioxane rate was measured by the oxygen uptake was using a manometric differential setup.It was shown that the compound (I) inhibit the 1,4-dioxaneoxidation. The effective rate constant of interactioncompound (I) with the 1,4-dioxane peroxyl radical was measured: fk7 = (5.1±0.3)·104l·mol-1·c-1. The stoichiometric inhibition factor calculated from induction period values is 1.5.
Keywords
- 4-dihydro-3H-pyrazol-3-one
- 1
- 4-dioxane
- radical chain oxidation
- peroxyl radical
- reaction rate constant